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Although clinical combinations with MDSC checkpoint inhibitors remain under exploration, theoretical models predict that blocking MDSC-mediated IL-10/TGF- signaling will sustain CAR-M M1 polarization and reinforce durable antitumor immunity (187)

However, there are no guidelines that address issues of systemic absorption, overall systemic risks, or other side effects of locally injected glucocorticoids

1999), formation of reactive nitrogen species (RNS) (Hinson et al

The process is non-invasive with each session taking only a few minutes

Occasional reports include temporary fatigue or lethargy (5-10% of users), mild headaches in the first few days of use, slight water retention, or transient flushing at injection sites