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10.1016/j.asjsur.2023.05.096 55

Because melanocortin receptors are involved in central regulatory networks, PT-141 is often incorporated into experimental models studying hypothalamic signaling, peptidereceptor kinetics, and neuropeptide-driven behavioral pathways in preclinical settings

Aghajani M

It also reduces uncertainty

By 2008, the manufacturer (Palatin Technologies) halted nasal formulation trials and pivoted to a subcutaneous injection route, which showed fewer cardiovascular side effects