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Yet, truly personalized probiotic strategies are still at an early stage: only a minority of studies stratify outcomes by host genotype, baseline microbiome configuration, or dietary pattern, and inter-individual variability in response remains poorly understood (5, 7)

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And there is a countervailing consideration the frequency logic tends to omit: more frequent stimulation of the ghrelin receptor raises the theoretical prospect of desensitization over time, so more pulses per day is not straightforwardly more effect, even on the models own terms

Fernndez Frontiers in Bioscience-Landmark.2024;[Epub] CrossRef Stimulation of non-shivering thermogenesis by bioactive compounds: A focus on gut microbiota-mediated mechanisms Yasmin Alhamoud, Tuerxunayi Abudumijiti, Junhao Wu, Lu Lu, Minjie Zhao, Xiaohu Luo, Fengqin Feng, Jing Wang Trends in Food Science & Technology.2024

SMSCs-derived sEV overexpressing miR-433-3p inhibits angiogenesis induced by sEV released from synoviocytes under triggering of ferroptosis