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StovnerLHagenKJensenRKatsaravaZLiptonRScherAet al

The paracellular and the transcellular endocytosis pathways are the most relevant for intestinal permeability, with most research to date focused on the paracellular pathway [21]

Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses