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What metabolic pathways make glutamate and why glutamine may not be the best nutrients to use if someone has excess glutamate

Multiple sclerosis, characterized by multiple demyelinating lesions of the spinal cord and brain, has a progressive neurodegenerative pattern (Manu et al., 2021

Along with the RPE cells high metabolic demand mentioned previously, which depends on free iron as an imperative cofactor and produces considerable amounts of ROS, these findings firmly correlate ferroptosis with RPE cell death

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