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Finally, in the case of drugs that induce (eg, carbamazepine) or inhibit (eg, fluoxetine) their own metabolism, 12,13 it is necessary to know what the half-life is at least 24 weeks after treatment initiation, when enzyme induction or inhibition reaches its peak

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Everything I've read can make sense in theory

Extremes matter: patients under 50 kg often do well at the lower end, patients over 100 kg may sit at the upper end of standard ranges

Cancer Treatments That Disrupt B12 Utilization Chemotherapy can also mess with vitamin B12