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One skilled in the art can readily determine an effective amount of cyclobenzaprine analog to be administered, by taking into account factors such as the size, weight, age and sex of the subject, the extent of disease penetration or persistence and severity of symptoms, and the route of administration

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Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1

The metabolism of the gut microbiome can also modulate antibiotic efficiency, as noted in high-fat diet-fed mice, such that the tryptophan metabolite indole-3-acetic acid promotes antibiotic efficacy against persisters 53