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NF-B within activated microglia also promotes inducible nitric oxide synthase (iNOS) that produces nitric oxide (NO) which in turn enhances S aggregation by impairing the ubiquitin-proteasome machinery (Tao et al., 2019)

The involvement of oxidative stress in the breakdown of immune tolerance is another crucial mechanism in the pathogenesis of autoimmune diseases

It takes 4 to 8 weeks before results (if any) are seen

Changes in GSH levels with time post dose were calculated as the difference in GSH/Cr peak ratios for each subject at each time point (GSH/Cr post dose GSH/Cr baseline ), or similarly, the difference in absolute GSH for each subject at each time point