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doi: 10.3389/fimmu.2019.00423 54 MuraoAAzizMWangHBrennerMWangP

Animal experiments After a 1-week acclimatization period, male C57BL/6 mice were orally gavaged with 150 mg/kg of metformin

Mechanistically, EPA and DHA effectively reduced CUMS-induced expression of IL-1, IL-6, TNF-, microglial marker M Integrin alpha M (CD11b), and increased expression of astrocyte marker glial fibrillary acidic protein (GFAP) by regulating the NF-B/p38 signaling pathway (Peng et al., 2020)

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the peptide or protein may be unmodified or may be modified, e.g., at its N-terminus, at its C-terminus and/or at a functional group in the side chain of any of its amino acid residues (particularly at the side chain functional group of one or more Lys, His, Ser, Thr, Tyr, Cys, Asp, Glu, and/or Arg residues)