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Despite ROS production may not play a crucial role in aging, it is more likely to provoke aging via oxidative damage and interaction with mitochondria [18]

Antioxidants Antioxidants are enzymatic or non-enzymatic agents that can prevent undesired oxidation through their reaction with ROS or oxidation intermediates (98)

Semin Neurol 10:4245 Lojo N, Rasic Z, Zenko Sever A et al (2016) Effects of diclofenac, l-NAME, l-Arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation deterioration in 24 hour-short-bowel rats