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Recombinant GSTP1-1 reference was obtained from earlier study in our group (Zhang et al., 2017a)

CBT-i addresses sleep-related behaviors and primarily consists of three main components [5, 9]: Sleep hygiene: Addresses abnormal sleep schedules (like a late bedtime), sleep behavior, and sleep disruptions, such as alcohol or electronics use

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187,188 Laboratory tests may reveal elevated inflammatory markers, including erythrocyte sedimentation rate or CRP, and nerve biopsy, though rarely performed, can demonstrate microvasculitis and perivascular inflammatory infiltrates

Treatments that claim to brighten focus either on slowing melanin production or speeding up the removal of pigmented cells