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Reducing Clostridium can inhibit the production of SBAs, prevent CYP7A1 from being inhibited by FXR and PXR, and ultimately increase cholesterol consumption

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Compared to the 25% of subjects with the lowest plasma TMAO levels at baseline, the 25% with the most TMAO in their blood were 2-3 times more likely to suffer a nonfatal heart attack, a stroke, or a fatal CVD event

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