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Hydration also plays a significant role

In a model of LPS- and IFN--induced RAW 264.7 murine macrophages, zerumbone was reported to dramatically decrease iNOS synthase and COX-2 protein production (Murakami et al., 2002

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However, if a specialized laboratory test is used, stable metabolites of the peptide can typically be detected for roughly 24 to 48 hours after administration, with some studies suggesting trace detection up to 4 days later