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Investigating blood samples from biobanks of human populations to identify systematic differences related to diseases can pose difficulties due to the existence of other sources of systematic variation

Xu and Imlay, 2012)

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Further, a randomized, double-blind, placebo-controlled trial in 81 healthy children, aged 8 to 14 years, reported that supplementation with a daily multivitamin/mineral for 12 weeks had no effect on various measures of mood (106)