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Proc Natl Acad Sci USA 1990;87:62586262 [DOI] [PMC free article] [PubMed] [Google Scholar] 73

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Allergic contact dermatitis due to cobalt will settle if contact with cobalt can be avoided

Much of this increase is explained by changes in diagnostic practice, including: Broadening the definition of ASD to include higher-functioning children Increased accuracy in the diagnosis of ASD (particularly for children who previously may have been diagnosed with intellectual disability) Increased awareness of the disorder Earlier identification of young children However, we cannot rule out that there is a true increase in the risk for ASD

In this sense, mathematical models revealed that a second enzymatic activity might have been implemented in vertebrate organisms in order to prevent NAM accumulation [39]