Proven Effectiveness : Clinical trials consistently demonstrate significant weight loss in semaglutide individuals
Severe caloric restriction sometimes impairs concentration and mental clarity, likely due to low glucose availability and potential micronutrient deficiencies
For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation
Full blood and reticulocyte count: Within 7 to 10 days of starting treatment and then after 8 weeks of treatment Iron and folate level (if not done already): After 8 weeks of treatment Neurological symptoms: Improvement begins within one week and complete resolution usually occurs between six weeks and three months
Vitamin B12 works by supporting several vital processes in the body
