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2 Pathophysiology of rheumatoid arthritis RA is primarily characterized by hyperplasia and inflammation of the synovium, leading to progressive destruction of cartilage and bone

The abundance of natural 13 C-labeled metabolite in ARP1 cells cultured with 13 C 2 -glycine was calculated by the following formula: abundance of natural 13 C-labeled metabolite = abundance of non 13 C-labeled metabolite P 0

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Comparisons among groups were performed by the Students t -test or one-way analysis of variance (ANOVA) followed by the Tukey test, while for multiple comparisons, Graph-Pad Prism analysis software (Graph-Pad Software, San Diego, CA) was applied