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Description

Sustained activation of the aryl hydrocarbon receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

PMID: 23 FujiwaraNMatsushitaYTempakuMTachiYKimuraGIzuokaKet al

The therapeutic window of vitamin B6 pathway inhibition Epidemiological observations and emerging metabolic evidence support two key mechanisms underlying the therapeutic window of vitamin B6 inhibition: a time-dependent tolerance gap between malignant and normal cells and metabolic vulnerabilities unique to cancer

doi: 10.3389/fnut.2021.782657 Received 24 September 2021 Accepted 18 October 2021 Published 23 November 2021 Volume 8 - 2021 Edited by Gang Wang, Shanghai Jiao Tong University, China Reviewed by Guoyuan Qi, University of Arizona, United States