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While HGH has anti-insulin effects, IGF-1 acts as an insulin sensitizer

Research on people susceptible to high-altitude pulmonary edema found that patients with elevated pulmonary artery pressure in high-altitude environments had increased free radical production and transpulmonary output in pulmonary blood vessels, increased pro-inflammatory cytokine production, and decreased NO bioavailability, suggesting that HAPH is related to free radical-mediated reduction in NO bioavailability [72]