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After mating them with UBC-Cre ERT2/+ mice, TLK2 genes could be knocked out ubiquitously by tamoxifen (Sigma #T5648) via intraperitoneal injection in 75 mg/kg body weight once every 24 h for a total of 5 consecutive days

doi: 10.1002/hsr2.291 226

Thus, they demonstrated that Prx2 prevents metHb aggregation, and, probably acts as a chaperone for the denatured Hb [96]

And indeed there, the animal data are pretty impressive

Osborne, MD, PhD, a cardiologist who specializes in hypertension and preventive cardiology and medical director of State of the Heart Cardiology in Southlake, Texas