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Standard peptide formulations often face delivery limitationsthis formula is designed with an absorption-enhanced system to support efficient topical application

R.HeimbrgerO.BrnyP.AnderstamB.et al (2015)

Compatibility of drug with the propellant and the metal canister and actuator, solubility or suspendability of drug in the propellant, possibility of nozzle obstruction, and very advanced design of the device are other concerns that may be challenging [11]

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Furthermore, potential risks of immune-modulating treatment during pregnancy are not specific to FcRn antagonists, as illustrated by the need for patients with TED to stop treatment with corticosteroids and anti-thyroid drugs when planning a pregnancy [344]