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[18] SSRIs, which mainly regulate serotonin, subsequently replaced tricyclics as the primary treatment option for depression because of their better tolerability and lower incidence of adverse effects

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doi: 10.3389/fcell.2021.765859 Received 27 August 2021 Accepted 25 October 2021 Published 29 November 2021 Volume 9 - 2021 Edited by Tugba Bagci-Onder, Ko University, Turkey Reviewed by Ilknur Sur Erdem, University of Oxford, United Kingdom Yansheng Feng, The University of Texas Health Science Center at San Antonio, United States Updates Copyright 2021 Tang, Huang, Huang, Chen, Huang, Liu, Ye, Zhao and Jia