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Primary and secondary bile acids and their oxo-derivatives have been identified as signaling molecules acting on a family of cell membrane and nuclear receptors, collectively known as bile acid-activated receptors. These receptors are highly expressed throughout the gastrointestinal tract and are crucial in mediating bidirectional communication between the gut microbiota and the host immune system

Another relevant isoform of NOS is inducible nitric oxide synthase (iNOS), which is expressed by glial cells such as astrocytes and macrophages

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ISBN 978-0-521-32831-9

Establishing a surveillance procedure for MDs in utero is difficult, above all in families without a mitochondrial disease history