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Since Diclofenac metabolites are mainly eliminated through the kidney, the patients with renal failure should be controlled closer than those with normal renal function

52,53 Furthermore, the activation of inflammasomes mainly manifests as an elevation of serum IL-1 and interleukin-18 (IL-18) and the recruitment of inflammatory cells

Although the exact cause is not always known, many cases are associated with compression of the trigeminal nerve by a blood vessel near its origin in the brainstem