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The applicant indicated that, while there may be cases where a second dose is needed, there is insufficient frequency to impact the reported weighted average of one dose per patient

J Biol Chem 284:2743827448

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Consistent with these metabolite levels, a HF-SAAR diet prompted a rise in the 13 C-labeling of liver serine and glycine in WT mice intravenously infused with [U- 13 C]glucose (Fig