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2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026

4.2 Formulation technologies and research advances: current dosage forms and doses 4.2.1 Dosage forms Advanced formulation techniques such as nanoemulsion (107), microemulsion (108), liposomes (109), and microencapsulation (110) have been widely applied to enhance the bioavailability and bloodbrain barrier permeability of TCM-derived polysaccharides, saponins, triterpenes, polyphenols, and carotenoids (111, 112)

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Funding The author(s) declare that financial support was received for the research and/or publication of this article