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In order to further analyze the metabolites in the eight groups, the fold change and p -value of metabolites between the groups were calculated and plotted as volcanoes, as shown in Figures 4B,D,F,H,J,L,N,P

Author contributions JB: Conceptualization, Visualization, Writing original draft, Writing review and editing

Disclosures: Nimmy Thomas: Nothing to Disclose, Christina Stull: Nothing to Disclose, Holli Sadler: Nothing to Disclose 1056 RISK OF INCIDENT EXTRAHEPATIC CANCERS AMONG MEDICARE PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH) Jesse Fishman 1 Yestle Kim 1 Joe Medicis 1 Matthew Davis 2 Dominic Nunag 2 Robert Gish 3 , 1 Madrigal Pharmaceuticals, Inc., 2 Medicus Economics, LLC, 3 Robert G Gish Consultants LLC Background: NASH, or metabolic dysfunction-associated steatohepatitis (MASH), is a severe form of non-alcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated liver disease (MASLD)

Over time, membrane deformability declines due to changes in lipid content and oxidative damage to proteins (61, 62)

TB-500 is often paired with BPC-157 in recovery protocols because the two peptides act through complementary mechanisms BPC-157 primarily through growth factor upregulation and angiogenesis, TB-500 through cell migration and actin dynamics