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SinghADAmicoDAndreuxPADunngalvinGKernTBlanco-BoseWet al

Other studies have complemented the upstream of this signaling pathway and showed that sUA induces IR in HUA by activating the Nrf2/HO-1 signaling pathway through up-regulation of the regulatory thioredoxin-interacting protein (TXNIP) in macrophages that inhibits IRS2/PI3K/AKT signaling pathway (57)

It is worth noting that although Scly / mice have reduced selenoprotein expression, they do not exert any of the Selenop / phenotypes like male sterility or severe neurologic defects (Raman et al., 2012