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For example, the modified FX polypeptides described herein include all those that contain one (s) substitution (s) of amino acid (s) with: S in a position corresponding to position 196, S in a corresponding position to position 211 and H in a position corresponding to position 219

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SLE patients also have lower hematocrit levels compared to healthy individuals and exhibit a higher percentage of PS-exposing erythrocytes, elevated cytosolic Ca 2+ levels, abundance of ROS, and significant erythrocyte shrinkage [327, 328]

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