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[16] After this initial phase, the frequency is reduced

In the absence of reliable tumor markers or imaging technologies for early detection of precursor lesions, it seems prudent to consider gonadal biopsies to exclude the presence of germ cell neoplasia in situ or gonadoblastoma in most individuals with 46,XY or 45,X/46,XY DSD with retained gonads

For example, a 2022 review highlighted the therapeutic potential of plant-derived compounds like Linalool in managing neurological conditions such as depression, showcasing how natural substances can modulate neurological pathways

It represents one of the complications associated with MetS

Nevertheless, melatonin also contributes to antiapoptotic activities via the Akt axis by preventing the decrease in pAkt and pBad levels upon HI injury 41,42 (Fig