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201204 ALDH2 can inhibit the activation of NLRP3 inflammasome by reducing the excessive accumulation of mitochondrial ROS (mtROS) and total intracellular ROS, thereby mitigating high glucose-induced pyroptosis in cardiomyocytes

The potential metabolic benefits of metformin, attributed to its action in the intestine, have also been highlighted

Cuprizone-induced demyelination is not lymphocyte-dependent and occurs even in lymphocyte-deficient recombination activating gene (Rag) knockout mice (Hiremath, 2008)

Earlier initiation may be appropriate in some cases, particularly when significant comorbidities persist

Infertility and sexual dysfunctions: a systematic literature review