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J Pharmacol Sci 108:227238 Massucci FA, DiNuzzo M, Giove F, Maraviglia B, Castillo IP, Marinari E, De Martino A (2013) Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective

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Additionally, in mice carrying APOE4, stress induces a loss of GABAergic neurons in the prefrontal cortex and hippocampal dentate gyrus, which may contribute to an increased risk of depression (Zhang J