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The role of FOXA family transcription factors in glucolipid metabolism and NAFLD

showed that AS-IV activates the PI3K/AKT/Nrf2/ARE signaling pathway, enhancing Nrf2 expression and nuclear translocation, binding to the ARE upstream, and increasing downstream antioxidant protein expression (e.g., Ho-1, Gpx-1, Gclc, and Gclm), which mitigates oxidative stress in glomerular mesangial cells (GMCs) induced by high glucose

Because the disulfide bridge (a cyclic disulfide) can undergo redox reactions, during the reactions catalyzed by the pyruvate dehydrogenase complex it is first reduced to dihydrolipoamide, a dithiol (the reduced form of the prosthetic group), and then reoxidized to the cyclic form

Il est utilis dans la recherche scientifique pour des tudes in vitro et in vivo

Hydrogen peroxide and superoxide radical anions are the main intracellular ROS, which are predominantly generated in mitochondria