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2.4 Inflammatory microenvironment Since Rudolf Virchow proposed the close relationship between inflammation and tumor in 1863, more and more studies have confirmed that chronic inflammation is an important marker of tumor occurrence and progression (3)

6 Inhibiting IGF-1R with teprotumumab, a mAb, has been shown to reduce the characteristic eye bulging (proptosis) and other serious clinical manifestations in patients with TED

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Since the liver is a major metabolic organ, liver disease is associated with metabolic diseases, such as obesity, insulin resistance, type 2 diabetes (T2DM), and cardiovascular disease