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GPX4 pathway activators The system Xc /GSH/GPX4 pathway plays a crucial role in suppressing ferroptosis mediated by lipid peroxidation reactions [13]

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Beyond the thyroid, DUOX enzymes are expressed on mucosal surfaces of the airways, salivary ducts, and gastrointestinal tract, where they supply H 2 O 2 to lactoperoxidase systems that support antimicrobial defense [32]