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4 Discussion In this preliminary, hypothesis-generating, prospective, double-blind, cross-over interventional study, we examined efficacy and mechanistic effects of a novel tear substitute containing 0.2% HA acid supplemented with 0.4% butyroyl-glutathione (i.e., GSH-C4) in patients with G-OSD

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Cytokines and chemokines play a crucial role in driving inflammation through their ability to activate endothelial cells, recruit immune cells to the synovial chamber, stimulate fibroblasts, and facilitate the accumulation of activated T and B cells (see Figure 1)

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