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also called LAP* and LAP) originate through regular translation initiation, and they are transcriptional activators

At least eight different inherited disorders of cholesterol biosynthesis are recognized in humans that lead to congenital abnormalities in those afflicted, including developmental malformation and neurologic defects, while deficiencies in the enzymes responsible for the hydrolysis of cholesterol esters, such as the lysosomal acid lipase, occur in Wolman disease and cholesterol ester storage disease

"A comparison of respiratory and peripheral muscle strength, functional exercise capacity, activities of daily living and physical fitness in patients with cystic fibrosis and healthy subjects"

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-KG can directly enter the TCA cycle, where it can be metabolized through oxidation and reduction