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The guidelines advise GPs that someone with B12 deficiency who has neurological symptoms should have every other day injections until no more improvements can be gained by this

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Importantly, stimulated mice exhibited increased expression of the axonal growth associated protein 43 (GAP43), suggesting that stimulation-enhanced recovery may enhance structural plasticity [92]

Whether you choose to inject or spray, the key is understanding WHICH peptides work best through WHICH routes