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Using in vitro studies, more than 60 cell lines were tested for the toxicity to high dosages of ascorbate

Olive oil provides polyphenols such as oleocanthal and hydroxytyrosol, which suppress NF-B activation and reduce pro-inflammatory cytokine release (159, 160)

In particular, the suboptimal pharmacokinetics and pharmacodynamics of these compounds and their poor ability to cross the BBB could represent considerable obstacles for a significant therapeutic efficacy

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This has been mainly attributed to the greater availability of sensitive and specific screening tests, which allow identification of the risk groups for CD and led to a significant raise in diagnoses worldwide [2,3,4,5]