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Increased synthesis of cholesterol and glycosphingolipids (GSLs) in SLE T cells leads to excessive lipid raft aggregation on the plasma membrane, enhancing TCR signaling and lowering the activation threshold for autoreactive T cells (160, 161)

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Glossary THIOL-REDOX REACTION A reaction that involves the transfer of electrons from a donor molecule to an acceptor molecule if one of the molecules is a thiol-containing compound