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However, additional data was gathered with the knockout mice that indicated that while AOD9604 did not lead to significant weight loss or increase in lipolysis without the beta(3)-adrenergic receptors, there was an increase in energy expenditure and fat oxidation

AOD 9604 typically has minimal side effects, but some individuals may experience mild discomfort at the injection site

NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat cells and other tissues that can become overactive in certain metabolic conditions

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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