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3 Biological characteristics and functional roles of EMT in RCC RCC cells undergo cytoskeletal reorganization, extracellular matrix (ECM) remodeling, and modulation of intercellular adhesion that is mediated by transcription factor regulation and supported by tumour-associated immune cells, enabling RCC cells to endure therapeutic stress and thereby facilitate invasion, metastasis, and colonization

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The impairment and uncoupling of ETC leads to the excessive generation of ROS, which further trigger a series of cellular injuries

So glutathione doesn't just protect collagen, it helps create the conditions under which more collagen can be built