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Acute versus chronic hypoxia: why a simplified classification is simply not enough

suppression of nuclear transcription factor B (NF-B) pathway (by the inhibiting the inhibitory subunit of NF-kB (IB) degradation

However, substituting the ethyl ester with an amide group, as in SRS9-11 (EC50 = 950 nM), resulted in a notable reduction in activity, though this finding was later contradicted by Hofmans et al