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After RSL3 treatment, the viability of A549 and HT1080 cells was significantly reduced by the combination of DHODH deletion and LDHB silencing compared to both single alterations and could be completely rescued by FER1 supplementation (Fig

Stroebel D, Buhl DL, Knafels JD, Chanda PK, Green M, Sciabola S, Mony L, Paoletti P, Pandit J (2016) A novel binding mode reveals two distinct classes of NMDA receptor GluN2B-selective antagonists