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Emphasis has been drawn to studies which recruited larger sample sizes and have reported diagnostic biomarker sensitivities and specificities (whereas many studies have not investigated diagnostic sensitivity or specificity)

Nishida Y, Ayoub E, Scruggs D, Khazaei S, Munir F, Ostermann LB, Mak PY, Baozhen K, Carter BZ, Baran N, Maiti A, Mohanty V, Chen K, Navin N, Haferlach T, Ren Z, Tong Y, Chen D, Issa GC, M Andreeff M

Washington, DC, USA: National Academies Press (2006)

Indeed, these time dependent HDT approaches are limited as they do not allow flexibility to manage disease through the course of an infection

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