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Authors' contributions JC made substantial contributions to conception and design of the study, acquisition, analysis and interpretation of data, revised the manuscript critically for important intellectual content, and was a major contributor to writing the manuscript

PMCs express TLRs such as TLR1, 2 and 5 excluding TLR4, which play an important role in the membrane inflammation process (Colmont et al., 2011)

In biochemical and cellular research systems, NAD+ has been investigated for its role in redox balance and as a substrate for NAD+-dependent enzymes

Trimethylamine-N-Oxide (TMAO) predicts cardiovascular mortality in peripheral artery disease

Start at lower doses to assess tolerance and adjust based on results