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NAC is generally more affordable and effective at boosting glutathione indirectly

Characterization of a rat Na+-dicarboxylate cotransporter

18 The treatment protocol for TPE consists of removing and retaining a considerable volume of plasma, approximately 1 to 1.5 plasma volume, 17 and returning the necessary cellular components via a colloid or combination colloid/crystallization solution of either fresh frozen plasma (FFP) or albumin

Additionally, the lack of methylation impairs the brain's ability to clear out neurotoxic metabolites, allowing them to accumulate and disrupt neural signaling