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These pathways are particularly significant for macromolecules and surface-modified particulate systems, where ligand attachment or mucoadhesive coatings may enhance epithelial interaction and promote uptake, thereby increasing the likelihood of transport via olfactory and trigeminal neuronal pathways (Dhuria et al., 2010, Pardeshi and Belgamwar, 2013)

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis

Biol Pharm Bull 20(8):825827 Shinohara K (1935) The determination of Thiol and disulfide compounds with special reference to cysteine and cystine

10.1089/ars.2006.8.274 136 OuttenC

For example, an increase in M1 macrophages may intensify inflammation and tissue damage, whereas a decrease could reduce inflammation