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USA 116 , 16211626 (2019)

The mode of action of -carotene in murine melanoma cells may conclude the blockage of Bcl-2, p53, and caspase-3, which then stimulates apoptosis and potency of -carotene upon tumor-specific angiogenesis, due to which tumor growth is affected

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Oxidative stress occurs when cells are exposed to ROS, such as superoxide anion (O 2 - ), hydroxyl radical (OH), hydrogen peroxide (H 2 O 2 ), and organic hydroperoxide (ROOH), which causes oxidative damage to the cell via interactions with cellular components, including lipids, DNA, and proteins [3]