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Description

The 2-oxoglutarate carrier is S-nitrosylated in the spinal cord of G93A mutant hSOD1 mice resulting in disruption of mitochondrial glutathione transport

ROS are produced after mitochondrial damage and, thus, mitochondria are both the source of ROS and target of ROS

Extracellular NM released from degenerating neurons is phagocytized by microglia, activating inflammatory responses and propagating neurodegeneration (265)